Pluristem Therapeutics Inc (PSTI)

[Spideyboy]

Hi Voova, just in case of any confusion, this isn't strictly placebo effect in the IC Phase II. Placebo would be based on doing no support at all, however the non-treated IC patients still had standard of care, supervised exercise.

It is normal part of current standard of care (SOC) for IC patients to undergo supervised exercise for about 3 months, because this can help with improving their situation. Again similarly in my prior-mentioned mouse studies of CLI, the mice that were not treated saw their recorded % blood flow, increase from baseline of 10% to 20%. This increase in blood flow is very likely to happen initially in IC patients too, with less severe disease, and with the supervised exercise, and the body doing what limited ability it can to increase the blood flow. Thus the SOC + placebo can show a statistically significant increase from baseline, due to the SOC.

The important thing is that PLX-PAD treatment was also statistically significantly higher than the SOC + placebo increase, demonstrating PLX-PAD's benefit.

But as you say due to the severity of the CLI situation and the more limited therapeutic options available compared to IC, the CLI results may perhaps be even more significantly beneficial.