Biotech Values

[DewDiligence]

Re: Structural differences Lucentis vs Avastin

>The "affinity maturation" step depicted in NEJM is what happens when you do the "phage display" in Retina. By phage display, they can screen variants to increase the affinity of the antibody fragment for the target. So yes, NEJM is condensed.<

The NEJM depiction does not show a starter human mAb. However, the Retina depiction shows both human and murine starter mAbs and some kind of hybridization step at the outset. Hence my question about whether the two depictions are consistent. Is it 100% clear that they are? T.i.a.