SLS—[re item #4 in your list]—Why does the relative risk reduction not equal 1-HR?
The relative-risk-reduction numbers reported in the PR refer to disease progression specifically, while the HR numbers in the PR refer to DFS. I.e., the discrepancy between the two sets of numbers is attributable to the number of death events.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”