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Re: mcbio post# 217469

Saturday, 02/24/2018 5:02:02 PM

Saturday, February 24, 2018 5:02:02 PM

Post# of 257323

...rapidly reducing viral loads to undetectable levels would seem to be what you would want in such a trial.

True—provided that the virus doesn't quickly become resistant to the drug.

I'm not saying ReViral's RSV fusion inhibitor won't work well, but rather that its MoA leaves a smaller margin for error than an N-protein inhibitor such as ENTA's, and it's more likely (IMO) that it would need to used in a combination regimen.

There may also be differences in safety/tolerability to distinguish the various RSV drugs in development.

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