Innovation Pharmaceuticals Inc (IPIX)

[slcimmuno]

NPR picked up the "pathogen hypothesis"
Brain Bug / how microbial infections may cause Alz
Amyloids like Peptides / Host Defense

Great backstory... lightbulb moment, kind of like DeGrado and friends scribbling PMX-30063 on a napkin, then actually -- with a lot of Super Computing heft -- designing it De Novo. Or Zasloff wondering why frogs, when cut, didn't develop infections. Magainin. Frog peptides.

Endlessly fascinates me how BRI arguably has improved on a key aspect -- peptides -- of the body's host defense.

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These peptides are "extremely important," Moir says. "They're not like legacies from an immune system we don't use anymore. If you don't have them, you're going to die in a couple of hours."

As Moir surfed through paper after paper, he realized that one of these ancient molecules, known as LL-37, looked a lot like a molecule closely associated with Alzheimer's. That molecule is called amyloid-beta and it forms the sticky plaques that tend to build up in the brains of people with dementia.

LL-37 and Amyloid-beta "looked just like peas in a pod," Moir says.

https://www.npr.org/sections/health-shots/2018/02/18/580475245/scientists-explore-ties-between-alzheimers-and-brains-ancient-immune-system

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