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Re: Titan V post# 217215

Saturday, 02/10/2018 12:39:56 PM

Saturday, February 10, 2018 12:39:56 PM

Post# of 257443
VKTX - thanks for the link to the definition of "Elevated Liver Enzymes" that they used in their trial. (It's clear from their material it wasn't the normal >3xULN, but hadn't yet found what they did use.) However I would suggest that there is still a significant risk since, as I noted before, the elevated bilirubin also shows up in the same dose cohorts.

That said, difficult to fully compare MDGL and VKTX since they aren't releasing fully comparable data. E.g. What is VKTX average liver enzyme change at each dose? Possible, although unlikely (because companies always tout good results), that average liver enzymes went down at lower doses.

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