You guys are missing the point. Any new app that is built using the .NET runtime will be able to run in 32 or 64 bit natively. .NET creates intermediate code, the runtime will execute it by converting to native code first. So, yes, existing apps will run in 32-bit mode fine on AMD64 but newer apps (most MSFT apps are being rewritten with .NET) will run in 64-bit mode natively.
CZ
p.s. I left java out because java has only made inroads as a back-end server language but java will also benefit from a 64-bit VM automatically.
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