Saturday, February 03, 2018 7:57:41 AM
..and remember, Agenus does have "unclassified.." work in their pipeline so they just may be another Peregrine collaborator, "ESPECIALLY" since we know see the facts that Dr. Jedd Wolchok was already working with Dr. Andrew Parsa... just as he is now working with Peregrine and the paradigm shifting technology of PS Targeting founded, discovered and advanced by the late Dr. Philip Thorpe
The new BODs should have a mission right now and that is to disclose all undisclosed program partners, all undisclosed targets that were being worked on and it would also seal the deal once all transcripts / depositions / court records unsealed, because was Peregrine IP of PS Targeting being used by Agenus? Very possibly yes
I say all should demand all records before any deal takes place because many shareholders will likely be shocked in the future ....to find out about certain collaborators and PS Targeting values as it is Right Now trying to be breadcrumbed out of our hands.
CHECKPOINT DEVELOPMENT PROGRAMS
Agenus has a portfolio of more than 10 antibodies that target both foundational inhibitory checkpoints, such as CTLA-4 and PD-1, as well as novel, cutting-edge targets that we feel could provide exciting opportunities as research continues to emerge on their potential. In addition to CTLA-4 and PD-1 our initial disclosed targets include GITR, OX40, TIM-3 and LAG-3. We also have many undisclosed checkpoint targets. Lead candidates for our CTLA-4, GITR, OX40 and PD-1 programs were discovered during an earlier collaboration with Ludwig Cancer Research.
http://agenusbio.com/pipeline/checkpoint-program/
It becomes more clouded now, WHY the new BODs are aligning up to block these requests and records....just ask why???
Read and listen to the video, all this was in perfect timeline of Peregrine past CEO Steve King disclosing dozens of "undisclosed Collaborations" and Agenus some as well...
Dr. Andrew Parsa, neurosurgeon at Northwestern Memorial Hospital, is creating a vaccine from the tumor itself to help the immune system target and suppress the cancer.
http://abc7chicago.com/archive/9546480/
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Northwestern Medicine Enrolls First Participant in Midwest for Research Study of Personalized Vaccine for Aggressive Brain Tumors
NORTHWESTERN MEMORIAL HOSPITAL
AUGUST 13, 2013
Randomized phase II trial will investigate vaccine therapy combined with Avastin for patients with recurrent glioblastoma multiforme
CHICAGO, IL – Northwestern Medicine® recently joined a landmark clinical trial to investigate if a vaccine made from a patient’s own brain tumor is effective in slowing tumor progression and extending survival. The randomized phase II trial will study how well giving the study vaccine with or without Avastin (bevacizumab) works in treating patients with recurrent glioblastoma multiforme (GBM). The study is the largest randomized brain tumor vaccine trial ever funded by the National Cancer Institute (NCI) and is chaired by Andrew T. Parsa, MD, PhD, who joined Northwestern Memorial Hospital in July as the new chair of neurological surgery. The first participant in the Midwest, and only third in the country, was enrolled in the trial last week at Northwestern Memorial.
The trial will enroll more than 200 participants with recurrent glioblastoma that can be surgically removed. Following the participant’s surgery, the tumor is sent to an industry collaborator Agenus Inc., where the participant’s specific personalized vaccine, designated as HSPPC-96, is created. The vaccine is unique to the individual participant and is engineered to trigger an immune system response to kill tumor cells that may remain following surgery.
“This is truly personalized medicine where the patient’s own tumor is being used to help fight their cancer,” said Parsa, who is also the Michael J. Marchese Professor and chair of the department of neurological surgery at Northwestern University Feinberg School of Medicine and a member of the of Robert H. Lurie Comprehensive Cancer Center of Northwestern University and part of the Northwestern Brain Tumor Institute. “The vaccine provokes a tumor-specific immune response that is specific to that patient. The T cells, which are the part of the immune system that fights disease, tracks down the cancer cells and kills them.”
Parsa launched this area of research in 2006 at the University of California, San Francisco (UCSF). Previous phases of this research have returned promising results finding that the vaccine extended survival for participants with glioblastoma when compared to standard therapies. In this next phase, researchers are seeking to understand if the vaccine is safe and more effective when given with Avastin, a drug that is known to shrink brain tumors and is a standard therapy for recurrent glioblastoma. Trial participants will be randomized to either receive the vaccine alone, concurrently with Avastin or Avastin only. Jeffrey Raizer, MD, co-director of the Northwestern Brain Tumor Institute (NBTI), is the principal investigator for the trial at Northwestern.
“This vaccine therapy has the potential to extend the lives of patients who often have limited options when their tumor returns,” said Raizer, medical director of neuro-oncology at Northwestern Memorial, associate professor of neurology at the Feinberg School and a member of the Lurie Cancer Center. “Previous results indicate that we may be able to extend survival longer by combining the therapy with other drugs, such as Avastin, that may boost the immune response of the vaccine.”
https://www.nm.org/about-us/northwestern-medicine-newsroom/press-releases/2013/northwestern-medicine-enrolls-first-participant#.U7F0u5RdU3c
There are many relevant posts this is connected to which gives high probability that Peregrines IP of PS Targeting was under collaborations with Dr Andrew Parsa and the question remains, WHY are records being hidden and remain closed....I mean since Renegade Roger Lias says the PS Targeting pipeline has only residual value ....
Then WHY are they hiding the residual research records of all collaborators? Why?
