Last evening at a retinal specialists association, my mother had a choice of Avastin or Lucentis for her wet AMD. We picked Lucentis because it's a smaller molecule which is the active portion of Avastin. We were informed that medicare completely covers Avastin off-label for that specific association. It sounds like Lucentis might have competition from the off-label Avastin for patients who can't afford Lucentis.