I.e., adding Squalamine to Lucentis produced a numerically worse outcome than Lucentis alone.
Squalamine failed in AMD more than 10 years ago, when it was owned by Genaera (#msg-136498116). The compound is a weak, “natural” anti-angiogenesis agent that was never subjected to any optimization by medicinal chemists. OHRP claimed that it would work as an eye drop, but treating a back-of-the-eye disease such as wet AMD with a topical form of a weak agent only serves to makes the agent weaker.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”
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