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Re: DewDiligence post# 955

Monday, 10/02/2006 9:45:46 PM

Monday, October 02, 2006 9:45:46 PM

Post# of 19309
Bad News

I am a little bit surprised at your lack of enthusiasm for this latest anouncement-alliance-dilution in light of your statements concerning the previous offering which was entirely money (and not very much). Perhaps I have the wrong idea but I see this partnership as the long witheld acceptence by the plasma protein producers. An acceptence which confers legitimacy on GTCB and on the whole transgenic process.
I have no basis to rebut your guess of 2013 as the market launch date for factorVIIa , but this seems rather gloomy estimate. Particularly since the plan is to use rabbits. FactorVIIa, historically a very lackluster member of the coagulation cascade compaired to its more famous cousins factorVIII and factorX (Christmas Factor), has become important because it can be used to by-pass many of the hereditary coagulopathies. It apparently is useful in some types of Von Willdebrand's (a platelet abnormality which can be corrected by factorVIII) and Glanzmans (?sp) a platelet disorder which the platelets loose their "stickyness". If available it might find widespread use in surgery.
It didnt seem from the anouncement the partnership was going to be limited to factorVIIa anyway. They mention other plasma prots as well as mono nuc abs. There's no reason GTCB should not be working on several projects at the same time. They are not trying discover new therapeutic agents, they are making known ones more readily available. I think this alliance could get them off their behinds.

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