Biotech Values

[Whalatane]

MDGL / VKTX. ...Titan et al , the problem I have with the view VK2809 is superior is that in addition to lowering TG's etc ..it RAISE'S liver enzymes ..
MGL-3196 lowers LDL, lowers TG's etc and also " significantly improves liver enzymes ."

I'm assuming with "Liver enzymes " they mean measurements of ALT and AST...please correct if necessary.

For the Hetero FH population ( of which I am one ) ...elevated Liver enzymes are always a risk as we are often on max dose Statins to lower our LDL cholesterol .
When I first started on Statins ..I was in a clinical trial pre approval ( 1987 ) ...the joke was that I'd either die of an MI or Liver failure .....thats how concerned they were about Liver damage

So any drug that raises Liver enzymes in the Hetero FH population is a tough sell IMHO .

If I have this wrong ...please correct
Thx
Kiwi

PS ...from reading the SA article ...note

. It would appear that the main issues is whether there are any adverse effects seen. In phase one trials, the most notable side effects were mild increases in hepatic enzymes (ALT/AST), and mild increases in serum lipids. This would be a reason to be cautious with long term use in geriatric patients,

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Mild increases in a healthy population ? ....right ...try that with a CAD , Hetero FH population on max dose of the strongest Stains ....as long term therapy
Statin plus Zetia plus MGL-3196 or VK2809 instead of injecting a PCSK9

When they run larger ( 1,000 patient ) trials I bet they will find more then "mild increases " in the Hetero FH population .....MGL-3196 gets my vote ( and I may even sign up for their P 3 trial )
JMO
Kiwi