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DewDiligence

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DewDiligence

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Re: pompart post# 34498

Tuesday, 09/26/2006 8:51:30 AM

Tuesday, September 26, 2006 8:51:30 AM

Post# of 257257
>It will be interesting to see if Quark et al have more luck than Merck & Alnylam did with in vivo delivery.<

I don’t think delivery per se is the limiting issue in RNAi treatment for AMD. Rather, the limiting issue is the need to produce Lucentis-like efficacy without unreasonably frequent intravitreal injections. Regards, Dew

p.s. Just to be clear: MRK/ALNY, Acuity Pharma, and AGN/RNAI are (were) pursuing (pursued) RNA interference of the VEGF gene, while PFE will be pursuing RNA interference of the RTP-801 gene.

“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”

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