Having a 1/3rd of your portfolio in one stock ...especially if its a large $ position ...is high risk no matter how well you think you know the known unknowns... let alone the unknown unknowns .
Should clarify: that ~30% figure refers solely to my taxable account (which I pretty much exclusively invest in biotech). My retirement account is in pretty broad-based index funds where I'm not taking a ton of risk. If you include both accounts, that would drop my largest holding down to roughly a 15% or so weighting.