With Bavituximab or BetaBodies one circumvents all that and simply bind PdSer (the LIGAND alike concept in PS world that binds PS-R the PS receptors).
BetaBodies don't rely on binding domains (b2gp1). However, would this circumventing create a paradox for attachment?
It appears obvious that eliminating binding traffic is paramount to success. In theory, statins would be synergistic in this regard, I/O combo's not so much, IMO.
I'm confident that this will eventually be tested. In the least, something similar to statin.
All the best, John
Disclaimer: Every post, and all my views are only speculative. Do not invest money or any other resources based on these post or opinions. Best of luck and do your own due diligence!