Avid Bioservices Inc (CDMO)

[vinmantoo]

This is a link to my post from more than a year ago it explains why Bavi likely isn't a good anti-cancer target when I tried to explain to CP why he was wrong.

CP wrote this following

Quote:
The PS exposes ONLY at damages cells and the PS receptors of 1 single immune cell is IRRELEVANT because there are already more then 10 well know PS receptors over the different cells.

You'dd need a 10-12 component combination to address and dose them all.

I responded with the following but I made a few changes today to correct typos and added a few words for more clarity.

The data for antibodies against a single type of receptor or a single ligand is very clear. These immune modulators show clinical efficacy in many different tumors as a single agent, and the FDA has approved then. In stark contrast, Bavi has failed not only as a single agent, but in combination with chemo. The evidence is piling up against your contention that you need to simultaneously hit all receptors. The next step is to combining immune modulators so that you hit both the receptor and ligand of one type (anti-PD-L1 and anti-PD-1), or different immune cells, such as a combinations that release inhibition to both T-cells ad macrophages. If you notice, nobody is rushing in to pay or make a deal with PPHM to use their Bavi antibody.

As far as PS, it is exposed on tumors cell, and on apoptotic cells. The latter providing a sink to draw off and reduce the Bavi that might be therapeutic. Estimates for PS exposure on Jurkat cells are 600,000 per cell, and this can reach 25 million. Estimates are that there are only 10,000 PD1 receptors on T-cells. If the same number of inhibitory ligands and receptors are expressed on tumor cells, you get a sense of why Bavi isn't the target of choice. If there were 10 or 12 different inhibitory receptors or ligands on a tumor cell, that adds up to about 100,000 receptors/ligands. Let's use the lower estimate of 1 million PS molecules exposed per tumor cell. Even if you could put enough Bavi in patients to bind 70% of the PS on each tumor cell, and I doubt you could even come close, there would still be 300,000 free PS per tumors cell. That is 3x the total number of inhibitory receptors/ligands expressed per tumor cell. You have way more PS than needed to bind the entire bank of 10-12 different inhibitory receptors/ligands.