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Re: DewDiligence post# 212364

Sunday, 07/16/2017 1:31:31 AM

Sunday, July 16, 2017 1:31:31 AM

Post# of 257266

MNTA’s M254 (hyper-sialylated Fc—a cheaper, recombinant alternative to plasma-derived IVIG) could potentially help with this problem.



Suggest that's unlikely? In this case the IVIG is being used for its immune reconstitution effects and presumably needs a full repertoire of Fab regions (pruned of auto reactive versions). (Most other uses of IVIG are immune damping and probably don't need the hypermutated Fab?).

Note: the reason for all the question marks is it is clear that IVIG is *very* complex and we don't fully understand why it works in different indications.

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