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Re: mcbio post# 212294

Monday, 07/10/2017 10:01:06 AM

Monday, July 10, 2017 10:01:06 AM

Post# of 257403

GKTX.PA—Did you make this post due to some specific issue you see in trying to develop an oral small molecule inhibitor against NOX? Is it a concern with the target itself? Concern with being able to hit the target? Or more a concern that this is a completely unproven target and approach?

None of the above, specifically. My quip at the bottom of #msg-127378262 was triggered by the sheer enormity of the company’s mission, as stated in the quoted text—especially this sentence:

Genkyotex’s therapeutic approach is based on a selective inhibition of NOX enzymes, which drive a broad range of disease processes, including fibrosis, inflammatory pain, angiogenesis, cancer growth, and neurodegeneration.


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