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Re: hutschi post# 297558

Tuesday, 05/23/2017 7:06:58 AM

Tuesday, May 23, 2017 7:06:58 AM

Post# of 347009
Hutschi so you think this Stafford knows John Stafford ...?

"PET imaging data showed that the prostate tumor-to-liver ratio was 22 for bavituximab compared with 1.5 for an isotype-matched control antibody at 72 hours postinjection. To obtain shorter blood residence times than those required for 74As-bavituximab imaging, Stafford and colleagues chose to use the F(ab')2 fragment of PGN635 (blood half-life ˜16 hours) conjugated with iodine-124, 124I (t1/2 = 4.2 days).33 Forty-eight hours after injection, PET imaging detected 124I-PGN635 F(ab')2 uptake in the PC3 prostate tumors in mice that was significantly higher than that of the 124I-labeled F(ab')2 of a control antibody..."

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