""""The physician–confirmed/unconfirmed overall response rate was 37% in the patients treated with chemotherapy plus PF-3512676 versus 19% in those treated with chemotherapy alone (P = .048).8 An independent radiologic review confirmed responses in 22% of the patients who received PF-3512676 versus 11% of those treated with chemotherapy alone. Median overall survival and the 1-year survival rate were moderately improved to 12.7 months and 50% with PF-3512676 compared to 6.8 months and 36% with chemotherapy only, although they did not reach statistical significance (hazard ratio 0.709; P = .16).""""