GTC Biotherapeutics (fka GTCB)

[DewDiligence]

>Can you end up having too much ATryn from a coagulation point of view while treating an inflammatory condition or is the process self-limiting as far as pro-thrombin times are concerned?<

Good question.

Provided that heparin is not given in large amounts simultaneously, I think AT dosing tends to be self-limiting because there is only so much AT that can bind with a given amount of heparin and it’s the heparin binding that gives AT its potency as an anticoagulant. I’d like to hear some of the science gurus (e.g. Aslan) weigh in on this question.