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Re: SF Wolf post# 851

Thursday, 02/16/2017 7:18:37 PM

Thursday, February 16, 2017 7:18:37 PM

Post# of 21531
There is nothing wrong with targeting plaques and tau, if you doing other things also

the problem with the BACE inhibitors and monoclonal antibodies target plaque is that is ALL they do.

Bryostatin activates the enzymes ECE, IDE and neprilysin, which inhibit plaque and inhibits GSK3 beta which inhibits tau formation, but in addition to that increases growth factors to restore synapses.

Multi modal mechanism, not one target
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