Treatment-naïve GT1 patients without cirrhosis were given 8 weeks of G/P and were analyzed in two subgroups: a) patients without the Y93H variant; and b) patients with the Y93H variant.
Among patients in a), the SVR12 rate was 99% (105/106); the only non-SVR12 patient was one who was lost to follow-up.
Among patients in b), the SVR12 rate was 100% (23/23).
CERTAIN-1 data from non-GT1 patients and various hard-to-treat subgroups will be presented later (at an undetermined medical conference). The ct.g listing for CERTAIN-1 is at https://www.clinicaltrials.gov/ct2/show/NCT02707952 .
Dew, I am a bit surprised this news didn't give at least a little boost to ENTA given only two drugs are used so ENTA's royalties will be higher if approved. Am I missing something?