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Re: cjgaddy post# 280441

Tuesday, 12/06/2016 6:58:20 PM

Tuesday, December 06, 2016 6:58:20 PM

Post# of 347009
CJ thanks! Dec 7th hours away...and hopefully Dr. Jedd Wolchok can shed some more light on how the non-responders will not be left behind.

12-7-16/WED 10am: JEDD D. WOLCHOK, MD/PhD(Mem. Sloan Kettering)
Lecture: ”Combination Checkpoint Blockade" (free to public)
Location: The Wistar Institute, Philadelphia (Jedd D. Wolchock: Chief of Melanoma & Immunotherapeutics Service, MSKCC)
https://www.wistar.org/events/2016/12/combination-checkpoint-blockade

...We don’t know if Dr. Wolchok will mention Peregrine/Bavi in his talk (North40000/Eb0783/Wook will let us know!), but RECALL that on 11-14-16, Dr. Wolchok’s MSKCC Lab Team, jointly with PPHM Scientists, presented a poster at SITC’16 on Triple Combo Rad+Bavi+aPD1 vs. Melanoma:
...11-14-16/SITC’16: Dr. Jedd Wolchok states, “Based on these study results, we believe that the targeting of PS is having meaningful activity within the tumor microenvironment in the B16 melanoma model. It appears that this activity creates a more immune active environment in which other treatments, including radiation, are able to have a greater anti-tumor impact.”
#199/SITC’16/11-11-16(MSK+PPHM): Phosphatidylserine Targeting Antibody in Combination with Checkpoint Blockade & Tumor Radiation Therapy Promotes Anti-Cancer Activity in Mouse Melanoma” See: http://tinyurl.com/js3fca4


"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline."
-- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!

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