(including the CEO's exercise-and-hold transaction: #msg-124809319) was a harbinger of a higher share price.
Just for the sake of showing an example to the contrary - PVCT insiders have never sold, and have completed numerous exercise-and-hold transactions as well as participation in share offerings. Including some that were months to years ahead of the final exercise date.
Offhand I can't tell you how often the stock was significantly higher within a given time frame, but I can say that the judgment involved in those purchases from an investment standpoint have so far been nothing short of horrendous if one only considers stock price.