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Re: DewDiligence post# 205372

Thursday, 10/20/2016 3:25:28 PM

Thursday, October 20, 2016 3:25:28 PM

Post# of 251888
Re: GILD HCV

I don't know.. looks pretty good to me. Commercially, what's important is that 95% SVR is achieved. The distinction between 95% or 98% is really not that meaningful. I for one, would not want to be treated 50% longer and pay 50% more to go from 95% to 98%. What's really important is that there was no adverse safety signal. They are still talking about this regimen as "salvage" but I just don't see why a regimen like this would not be positioned as the go-to regimen for everyone (8w for DAA naive, 12w for DAA experienced). Otherwise, they are making themselves vulnerable to an 8w regimen from a competitor that could also hit 95% SVR. So, my take on this is that SOF/VEL/VOX delivered good enough efficacy to become the new SoC and Gilead would be stupid not to position it that way.

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