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Re: mcbio post# 188317

Wednesday, 09/28/2016 4:23:12 PM

Wednesday, September 28, 2016 4:23:12 PM

Post# of 257301
ENTA starts phase-1 trial of NASH compound, EDP-305:

http://finance.yahoo.com/news/enanta-pharmaceuticals-initiates-phase-1-201200159.html

EDP-305 is an FXR agonist—the same drug class as ICPT's OCA and GILD's GS-9674 (acquired from PFNX in 2015: #msg-109653984).

ENTA has asserted that EDP-305 is substantially more potent than ICPT's OCA—see slides 24, 26, &27 at http://jpmorgan.metameetings.com/confbook/healthcare16/stash/slides/19782/confbook_slideshow.php .

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