GTC Biotherapeutics (fka GTCB)

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Severe sepsis overview

Societal impact of severe sepsis

Severe sepsis is one of the most significant challenges in critical care. Consider these facts:
More than 750,000 cases of severe sepsis occur annually in the U.S.
There are 3.0 cases of severe sepsis per 1,000 population and 2.26 cases per 100 hospital discharges.(Angus,2001)
The hospital cost of treating patients with severe sepsis in the U.S. is approximately $17 billion each year.(Angus,2001)
Severe sepsis causes 215,000 deaths in the U.S. each year—more than AMI, lung cancer, and other commonly known causes of death in the hospital.(Angus,2001)


Surviving severe sepsis
Mortality rates of severe sepsis has remained constant or decreased only slightly, while incidence of the condition has grown during recent decades.(Friedman,1998) Despite advances in infectious disease and critical care, along with numerous attempts to develop treatments, the mortality rate of severe sepsis and septic shock remains unacceptably high.(Dellinger,2003),(Friedman,1998)

Comparison of deaths associated with severe sepsis to those from other diseases, United States(Minino,2004)

Next steps

Understand which types of patients are most likely to get severe sepsis.
Learn about the impact of sepsis and severe sepsis on institutions.
Learn how Xigris can help reduce the costs of severe sepsis.

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