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Re: JohnWayne post# 203189

Friday, 08/05/2016 1:42:33 PM

Friday, August 05, 2016 1:42:33 PM

Post# of 257268

Curious what makes you think Opdivo + Yervoy is a long shot, I thought the Phase 1 data from ASCO were extremely impressive?



The yervoy data as monotherapy are not particularly impressive, and my hunch is that a pd-1 plus chemo is likely to be better than pd-1 plus ctla4. the benefit of yervoy was mostly w chemo in the large ph 2, and BMY is not adding chemo to the combo (likely due to toxicity)
as for the combo data at asco i agree it was promising, but the numbers were pretty small. I also seem to recall that yervoy alone or w chemo did better in PD-1 negative (i could be remembering incorrectly couldn't easly find the data by googling), whereas in the ph 1 the combo only seemed to work in pd-1l expressors, so that jsut seemed peculiar

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