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Re: dewophile post# 203154

Friday, 08/05/2016 12:01:41 PM

Friday, August 05, 2016 12:01:41 PM

Post# of 257268
BMY - Monumental surprise. Interesting that BMY very explicitly described 5% cutoff as primary endpoint, on recent investor calls it's sounded like they were conducting a hierarchical analysis that would have started at higher cutoffs. Will be very interesting to see data at 10%, 25%, 50% cutoffs, but seems like a stretch to expect any regulatory path forward even if those data are good.

Still think BMY is well positioned in 1L NSCLC with combo trials, but this failure certainly casts a spectrer over their program.

Also, of note, it's the very first Phase 3 failure for a PD-1 inhibitor.

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