Today’s PR is the first time BMY disclosed the PD-L1-expresssion threshold (≥5%) in CHECKMATE-026.
In retrospect, we can surmise that Opdivo would’ve had a better chance in first-line NSCLC if they had chosen a higher PD-L1-expression threshold than 5%; however, this was an instance where the science and the business exigencies were pulling in opposite directions.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”