you can potentially save someone from dying tomorrow from a SAE, then regroup and potentially use another curative therapy - hell you can use the SAME therapy at a lower dose and get a cure If i were a pt, especially at this juncture, I'd prefer to have an off switch built in. Once the tech matures as PGS says it may be less meaningful but even then if there is a very low say 2% risk of death still better to shut things down and live to fight another day IMO