I believe the primary signal that is being sought in the small trials is the actual extent of the ‘Brekken Effect’ in human patients. I think Dr. Brekken,TexSW, is a straight shooter when he makes claims that come from his lab work. We need to see how it actually translates in trials.
Being a straight shooter has nothing to do with it. One needs to recognize that results from cell lines and mouse models very frequently don't replicate in human trials.