Momenta Pharmaceuticals, Inc. (MNTA)

[jbog]

…it doesn't seem like many oncs are encouraging their patients into the phII portion of the trial.

I would have thought the 'B' part of the Trial would have been very easy to populate.

Rather than Us trying to figure out the pro's or con's of this trial I find it easier to see how the Onc's react to the data. They see and talk about the results.

If we look at the MPACT trial, which was a 830 patient PhIII trial combining nab-paclitaxel and gemcitabine it took them about 2 years to populate with readouts in years 3 and 4.

The B part of the necuparanib trial in combination with nab-paclitaxel (nabP; Abraxane®) and gemcitabine (gem) doesn't have many eligibility roadblocks and only needs a total of 180 pts (? less part A ).

If you consider that there is a probable patients base of 75k patients per year you would think grabbing 180 of them would be an easy task. Keep in mind the 'Control Arm' is given Standard Care so there is zero risk in entering the trial.

I see that if after 20 months and the trial is yet to be fully enrolled that the Onc's aren't very excited.

O'Rielly isn't a rookie in pc.

Clinical Trials Led by Eileen M. O'Reilly

A Phase I Study of MVT-5873 Alone or with Chemotherapy in Patients with Pancreatic Cancer and Other CA19-9 Positive Tumors

A Phase I/II Study of Immunotherapy with Ulocuplumab plus Nivolumab in Patients with Pancreatic and Small Cell Lung Cancers

A Phase I/II Study of M402 in Combination with Gemcitabine in Patients with Previously Untreated Metastatic Pancreatic Cancer

A Phase II Study of MEDI4736 Alone or in Combination with Tremelimumab in Metastatic Pancreatic Cancer

A Phase III Study Comparing Gemcitabine plus nab-Paclitaxel to Gemcitabine Alone After Pancreatic Cancer Surgery

A Phase III Study of Capecitabine with Ruxolitinib or Placebo to Treat Advanced Pancreatic Cancer

Two Phase II Studies of Veliparib for Pancreatic Cancer with a BRCA or PALB2 Mutation: Gemcitabine & Cisplatin with/without Veliparib in Untreated Pancreatic Cancer (Part I) & Veliparib Alone for Patients with Previously Treated Pancreatic Cancer (Part…


Clinical Trials Co-Investigated by Eileen M. O'Reilly

A Phase I Study of Stereotactic Body Radiotherapy after Chemotherapy for Locally Advanced Inoperable Pancreatic Cancer

A Phase III Study of Olaparib versus Placebo as Maintenance Therapy in Patients with BRCA-Mutated Metastatic Pancreatic Cancer with Stable Disease after Platinum-Based Chemotherapy

A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Pancreatic Cancer

A Two-Stage Pilot Study of PEGPH20 and Cetuximab in Patients with Pancreatic Cancer When Given Before Tumor Removal