By: buck45 $$ Reply To: None Wednesday, 27 Sep 2000 at 2:59 PM EDT Post # of 134
Block Buster United States Patent Issues Yesterday 6,124,430 Mischak , et al. September 26, 2000
Human brain natriuretic peptides
Abstract
The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes comprising the amino acid sequences 5-13, 1-10 and 15-25 of hBNP. These antibodies, and peptide fragments containing these sequences, can be employed in the assays of the invention, which may be carried out in a sandwich format or a competition format.
Inventors: Mischak; Ronald P. (Palo Alto, CA); Lim; Garrett A. (Havertown, PA); Scardina; Jan Marian (San Carlos, CA) Assignee: Scios Inc. (Sunnyvale, CA) Appl. No.: 942332 Filed: October 1, 1997
U.S. Class: 530/324; 436/544; 530/327; 530/839; 530/841 Intern'l Class: C07K 014/47 Field of Search: 436/544 530/324,327,839,841
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