Intellect Neurosciences Inc. (fka ILNS)

[Dubb10]

It appears Shire's had interest in Friedreich's Ataxia for awhile now.

Jun 15, 2012 - Shire Human Genetic Therapies, Inc.

The present invention provides, among other things, compositions and methods for treatment of Friedrich's Ataxia based on effective targeting of a therapeutic moiety to mitochondria that can substitute for natural FXN protein activity or rescue one or more phenotypes or symptoms associated with frataxin-deficiency. In some embodiments, the present invention provides a targeted therapeutic comprising a therapeutic moiety, which is a polypeptide having an N-terminus and a C-terminus, a mitochondrial targeting sequence associated with the therapeutic moiety at the N-terminus, and a mitochondrial membrane-penetrating peptide associated with the therapeutic moiety at the C-terminus, wherein the therapeutic moiety is targeted to mitochondria upon cellular entry.

Patent History
Patent number: 9260495
Type: Grant
Filed: Jun 15, 2012
Date of Patent: Feb 16, 2016
Patent Publication Number: 20140135275
Assignee: Shire Human Genetic Therapies, Inc. (Lexington, MA)
Inventors: Dennis Keefe (Wilmington, MA), Michael Concino (Bolton, MA), Michael Heartlein (Boxborough, MA), Serene Josiah (Cambridge, MA), Bettina Strack-Logue (Somerville, MA)
Primary Examiner: Alexander Kim
Application Number: 14/127,074

patents.justia.com/patent/9260495

I believe most of the inventors are still with Shire.

Not to be a conspiracy theorist, but the "accumulation" of ILNS ramped up back in mid Feb. Just throwing poop against the wall to see if anything sticks. It's the OTC world after all. :)
http://stockcharts.com/h-sc/ui?s=ILNS&p=D&b=5&g=0&id=p14028053836