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Re: semi_infinite post# 200667

Thursday, 04/07/2016 4:01:11 PM

Thursday, April 07, 2016 4:01:11 PM

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In RVNC’s BELMONT study, the 2-point response rate at 28 days was 85% in the RT002 40U arm (the dose being advanced to phase-3) and was 76% in the Botox arm—see slide #17:

http://investors.revance.com/common/download/download.cfm?companyid=AMDA-2GNRV0&fileid=879866&filekey=49C43CF1-9EAE-4E93-9666-420214DA7486&filename=RVNC_Company_Presentation_March_2016.pdf

So, Alphaeon’s 68-70% is low.

Note: It is immaterial whether the response rate is measured at 30 days (in the Alphaeon trials) or at 28 days (in RVNC’s BELMONT study)—both time points should capture the maximum treatment effect.

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