>> If CGRP “really is a fundamental mechanism, you would expect a much higher proportion of patients to be completely free of attacks,” Ferrari says.
That's a stupid statement. There are multiple different migraine subtypes and no particular reason to assume they will all respond the same way to any intervention. Or the PK can be different in different patients.
On long-term safety, who knows. CGRP knockout mice basically do OK, but the protein is involved in blood pressure regulation, bone formation and assorted other disparate things.