Avid Bioservices Inc (CDMO)

[Protector]

md, Massagué knew about Doctor Thorpe's work.

Massague was among others involved in affinity labelling techniques of membrane molecules. And who was an authority in membrane molecules (e.g. phosphotidylserine (PS))? Yes, our Doctor Thrope.

One of the concerns in labeling is the effect the binding will have on the bodies biology (it's functioning). In other words if you link a label molecule to a membrane molecule (simplified statement) then what will happen? Will the membrane molecule still perform its role or is the linkage responsible to disable it or change its behaviour.

Thorpe knew a lot about these effects from his own research.

INVESTIGATION OF MEMBRANE-LOCATED RECEPTORS

#C HOMING OF CIRCULATING PEPTIDES, PROTEINS AND DRUG CARRIERS ...... 249

Massagué's work on the topic:

#C-4 Affinity labelling techniques for low-abundance membrane components: peptide hormone receptors and the D-glucose transporter

JEFFREY E. PESSIN, JOAN MASSAGUE & MICHAEL P. CZECH .............. 295

Thorpe's Notes

#NC(C)-5 Targeting toxins by conjugation to antibodies: the effect of the linkage group on biological activity
D.C. EDWARDS, W.J.C. ROSS, A.J. CUMBER, D.P.MCINTOSH, A. SMITH, P.E. THORPE, A. BROWN, R.H. WILLIAMS & A. J • S. DAVIES ............... 357

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Search for Massagué and for Thorpe.