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Re: ghmm post# 198365

Wednesday, 12/23/2015 1:18:19 AM

Wednesday, December 23, 2015 1:18:19 AM

Post# of 257443
LGND -

Its one stock I sold WAY too early and regret since I sold to raise cash thinking it was ahead of itself.

Same with me. Was chatting with someone tonight and it caused me to re-think LGND. Seems like nearest big potential value driver could be if MRK P3 for MK-8931 (BACE inhibitor to which LGND is due undisclosed royalties) shows any positive hint of efficacy. The person I was chatting with mentioned that no other AD drug has advanced to P3 to date having shown the ability to lower soluble forms of amyloid beta in the clinic (as apparently MK-8931 has). Anyone have any comments on likelihood this will differentiate MK-8931 from the litany of prior AD drugs targeting amyloid beta that have failed in the clinic?

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