the risk of allergy is likely extremely low Yes - the first time you use it. But it does seem to induce problems with repeated use: <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=14656362&query_hl=1&itool=pubmed_docsum" target="_blank">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_...</A> I would expect that as Bovine Thrombin continues to grow its market the problems will become worse.