Biotech Values

[DewDiligence]

>Dew, are GI side affect [of NM283] so unbearable that a treatment refractory patient will be willing to allow the hcv virus to continue its destructive course because of it?<

At 800mg/day, the GI side effects were bad enough to cause a high percentage of patients to drop out of the phase-2b trial. At 200-400mg/day, on the other hand, the side effects appear to be manageable.

The question for NM283 in the treatment-refractory setting is whether there is a way to attain the efficacy seen in the 800mg cohort without the severe side effects.