ANDS
I'd hoped there would be more detail on the problem by now. The "intense immune stimulation " in the preclinical studies that caused them to stop dosing humans must have had an autoimmune component , since immune stimulation was precisely what they were trying to do in the first place.
Ironically , evidence of autoimmunity caused by ANA975 could turn out to have a bright side , provided the autoimmune effects are not sufficiently severe or long-lasting to prevent further development. As recent cancer immunotherapy studies have shown , autoimmune side effects may correlate with anticancer effects , as they signal a reversal of immune tolerance. Chronic viral infections are also characterized by immune tolerance , and the most efficacious HCV drug on the market today , interferon , is also known for autoimmune side effects and exacerbation of existing autoimmune disease.
This might a treatment area where it's necessary to tolerate quite a bit of bad in order to get the good.
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