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Re: DewDiligence post# 30386

Wednesday, 06/21/2006 7:28:37 PM

Wednesday, June 21, 2006 7:28:37 PM

Post# of 257300
slight correction

Lucentis is not an antibody fragment of Avastin, although this is often misquoted in the media

Instead, Avastin and Lucentis were derived from the same parent murine antibody (brothers) Lucentis has been tested in a large evidence based program. It is smaller to better penetrate the retina and is affinity matured to better block VEGF (in theory). Avastin has been used anecdotally and there is no safety database, so safety issues are unclear.

Avastin clearly works better than the current treatements on the market, but if I had a family memeber with w AMD, I would wait the 1-2 weeks and get Lucentis. Having saifd that, 3 months ago, i would ahve recommended avastin

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