Innovation Pharmaceuticals Inc (IPIX)

[BonelessCat]

We don't know if the 11 cohort is done. The 3 original patients surely have finished, but I have seen nothing that states the cohort complete and cohort 12 started. CTIX received permission to expand the trial by up to 20 more patients. We don't know yet how the trial expansion is applied. It could be up to 20 more at 750 or it could be 3 more at an escalated dose for cohort 12 with a determination for the final 17, return to lower dose or expand 12 as the final cohort. They might even reduce the dosage to 450 which would expand cohort 10. This would be to reduce the chance of another DLT event so that all 20 patients could complete dosing cycles with out the complication of a possible DLT and forced application of MTD that would cause more delays for completing the trial. As far as cohort and dose is concerned, there are too many unknowns to effectively predict these final days of the Kevetrin Phase 1 trial.