Avid Bioservices Inc (CDMO)

[asmarterwookie]

Top O' the MUMs the Word Monday Peregrine!!!!!!!!

Yup....Peregrine will not release anything today, in case you were wondering.

Science question I've been pondering........

I always see "signaling pathway" when reading about immunotherapy....

I've always envisioned PS Targeting and the APP as changing the signal one cell at a time...ie an individual cell signal. Pondering the "signaling pathway" angle...is the exposed PS more than just a single cell signal? Does exposed phosphatidlyserine on one cell have a signaling effect on it's neighbor without exposed PS? Hard to put in words but I am thinking of PS as a stone tossed into a lake....the ripples(energy) that the rock caused eventually reach the shore, even though the rock never touched the shore. Do healthy, non-apoptotic cells recognize exposed PS on it's neighbor and pass along the "eat-me" message, cell to cell until it reaches a nearby macrophage, dendritic and other immmune cells?

The question... Is the PS "eat me"signal passed along and through the microenvironment through other processes/molecules/signals associated with the immune system?

I understand the "other" checkpoint inhibitors but I mean the specific PS signal being "translated" and passed along through the inter-cellular pathway....ie...from an apoptotic cell along a number of healthy cells...until a macrophage or other cell gets the message to mobilize in their amoebic manner to engulf the dead/dying/cancerous cell.
NOW.....does that path act as a "track" for the macrophage to follow to the bad cell? The macrophage doesn't have GPS(as far as I know) to find the bad cell so it must be guided somehow....right? If so...what is the track they follow?

I hope this makes hypothetical sense.

A note on Dr Jeff Hutchins.....a brilliant mind and a really cool guy from AACR...Stephen Worsley as well...

Let's hope they are as on top of their game as I perceived....Hutchins being chairman(as well his other achievments) gives him the "on your game check"! Hutchins, what gives you the "on your game" check? Show us the money!

Enjoy the Day!

wook