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TOB

Re: BonelessCat post# 108620

Thursday, 06/18/2015 6:35:19 PM

Thursday, June 18, 2015 6:35:19 PM

Post# of 405181
Much appreciate you sharing your email exchange with the CTIX CEO.

Excellent and informative questions and answers. Good to see everything is on-track, and especially that they are taking steps to accelerate the Brilacidin-OM trial. If the Brilacidin-OM results are good, we will have a surprise home-run. I don't think a penny of Brilacidin-OM is priced into the current share price.

Very intriguing about the Kevetrin clinical trial at Harvard Cancer Centers. Something is clearly in the works to speed-up the conclusion of the trial methinks. But I'm happy to wait for the actual details in the coming update.

Personally I'm also happy if they just continued the Kevetrin trial with higher doses. But they must have some basis for wanting to move faster to a next stage clinical trial. No question a positive Phase 1 Clinical Trial primary outcome measure is all but certain at this point. This has been the case since I first wrote that... was it a year ago? When the Kevetrin trial had proven safety into the range believed therapeutic. It only becomes more likely factual as higher doses are proven safe.

IMO additional indications of Kevetrin efficacy adding to those we've heard about, and PK data suggesting more frequent dosing is needed for full therapeutic effect are the only reasons there would be interest in wrapping up the trial without pushing to the highest doses. I can't imagine any other explanation for the below quote. Without indications of efficacy I'd think they'd want to keep trying higher doses.

However I will say our optimism on Kevetrin is unchanged and we want to move into Phase 2 ASAP. When I update on Brilacidin I will do a complete corporate update as well. - CTIX CEO Leo Ehrlich





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