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Re: genisi post# 191644

Saturday, 05/23/2015 5:58:34 PM

Saturday, May 23, 2015 5:58:34 PM

Post# of 257314
Right! Wild-type FVIII cDNA is too large to fit into the AAV8 vector, so BXLT switched to an FVIII variant, which also increased gene expression in animal models. Whether the increased gene expression was the result of luck or skill is unclear to me.

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