Biotech Values

[mcbio]

>>Is FGEN the only one currently targeting CTGF for fibrosis?

To my knowledge, yes.

CTGF is clearly intimately involved with fibrosis, but I wouldn't call it a magic bullet. Fibrosis is very complex and there are weird feedback loops with e.g., TGF-beta.

The FGEN drug was able to reverse radiation-induced lung fibrosis in an animal model - as far as I know that is the only demonstration of reversal of fibrosis in the literature.

FWIW, Corbus claims their drug reduces CTGF and TGF-beta: http://www.corbuspharma.com/news/press-releases/detail/174/corbus-pharmaceuticals-announces-presentation-of-positive .