AAVL: Ohad took a position in his model portfolio but acknowledged it as high-risk, high-reward. http://www.orf-blog.com/will-2015-mark-the-turnaround-for-antibody-drug-conjugates/#comments I wonder how a basket of these high-risk, high-reward stocks will do. No position in AAVL though I do own one high-risk, high-reward that has been discussed on this board of late :-).